Bad Actor chemical, it is a known reproduction or developmental toxin and a suspected endocrine disruptor. Each document posted on the site includes a link to the iv. Register documents. 2. documents in the last year, 401 That notice referenced a summary of the petition prepared by Valent USA Corporation, the registrant, which is available to the public in the docket, http://www.regulations.gov. Uniconazole is an insecticide. plugs). You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. Cancer. on Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to establish, modify, or revoke a tolerance, the Agency consider available information concerning the cumulative effects of a particular pesticide's residues and other substances that have a common mechanism of toxicity.. of the SUPPLEMENTARY INFORMATION). Piperonyl butoxide is an organic compound (a semi-synthesized derivative of safrole) that isnt a pesticide on its own, but rather is mixed with certain pesticide compounds as a synergist to increase their potency. It is a neurotoxin and works by slowing down the nervous system through binding sodium channels. Aggregate Risk Assessment and Determination of Safety, D. Safety Factor for Infants and Children, E. Aggregate Risks and Determination of Safety, VI. It is highly effective in controlling growth of seedlings in plug flats, and it is most effective in cooler climates. The restricted-entry interval for Concise or Sumagic is 12 hours. Mediacom Communications today named Tapan Dandnaik as Senior Vice President of Operations, Product Strategy, and Consumer Experience. The North American Industrial Classification System (NAICS) codes have been provided to assist you and others in determining whether this action might apply to certain entities. establishing the XML-based Federal Register as an ACFR-sanctioned documents in the last year, 829 21 U.S.C. If you have any questions regarding the applicability of this action to a particular entity, consult the person listed under FOR FURTHER INFORMATION CONTACT. To support existing tolerances and to establish new tolerances for triazole-derivative pesticides, including uniconazole, EPA conducted a human health risk assessment for exposure to 1,2,4-triazole, triazole alanine, and triazole acetic acid resulting from the use of all current and pending uses of any triazole-derived fungicide. Publicly available docket materials are available in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. Specific information on the studies received and the nature of the adverse effects caused by uniconazole, as well as the no-observed-adverse-effect-level (NOAEL) and the lowest-observed-adverse-effect-level (LOAEL) from the toxicity studies, can be found at http://www.regulations.gov in the document Uniconazole-P Human Health Risk Assessment for Proposed Uses on Fruiting Vegetables (Except Cucurbits), Crop Group 8 pages 52-75 in docket ID number EPA-HQ-OPP-2007-1199. include documents scheduled for later issues, at the request %PDF-1.5
documents in the last year, 85 The prenatal and postnatal toxicology database for uniconazole includes rat and rabbit developmental toxicity studies and a 2-generation reproduction toxicity study in rats. 2 0 obj
Use the PDF linked in the document sidebar for the official electronic format. documents in the last year, 129 Kill it. <>
In the reproduction study in rats, higher doses resulted in minimal pup toxicity (slightly reduced body weights); and: The NOAEL for the fetal effect is used for assessing acute risk of females 13 years and older and is, therefore, protective of potential developmental effects. Therefore, 40 CFR chapter I is amended as follows: 1. Section 408(b)(2)(C) of FFDCA requires EPA to give special consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue. They are particularly potent at attacking the nervous systems of insects. Permethrin is a common and widely used ingredient in insecticides and insect repellents. All documents in the docket are listed in the docket index available in regulations.gov. Z5jf8gSU)(P +j:{FR|oV3yI :_\u?}z[-^q(!!
Frontiers | Transcriptomic and metabolomic analyses reveal the Register, and does not replace the official print version or the official 2. Pyrethrins are a class of organic compounds derived from certain members of the Crysanthemum genus. Uniconazole | C15H18ClN3O | CID 6436604 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . In the United States a product called Fresco is labeled for this use. We comply with the HONcode standard for trustworthy health information. Uniconazole is applied as both a foliar spray and as a substrate drench. Under section 408(g) of FFDCA, any person may file an objection to any aspect of this regulation and may also request a hearing on those objections. iv. In addition to filing an objection or hearing request with the Hearing Clerk as described in 40 CFR part 178, please submit a copy of the filing that does not contain any CBI for inclusion in the public docket that is described in ADDRESSES. Therefore, most of the commercially available growth retardants function by inhibiting gibberellin synthesis in the plant. documents in the last year, 38 Your email address will not be published. Flurprimidol is also one of the most cost effective growth retardants to use as a drench, with recommended application rates in a similar range as uniconazole on most plants. This document has been published in the Federal Register. 2. The risk assessment is a highly conservative, screening-level evaluation in terms of hazards associated with common metabolites (e.g., use of a maximum combination of uncertainty factors) and potential dietary and non-dietary exposures (i.e., high end estimates of both dietary and non-dietary exposures). For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see EPA's website at http://www.epa.gov/pesticides/cumulative. lists acute toxicity risk as slight, research indicates it may be a carcinogen with water contamination risks, even earning a spot on the E.P.A.s carcinogen watch list. EPA determines whether acute and chronic pesticide exposures are safe by comparing aggregate exposure estimates to the aPAD and cPAD. Federal Register issue. Imidacloprid is a systemic insecticide and a member of the neonicotinoids class of chemicals. Submit this copy, identified by docket ID number EPA-HQ-OPP-2007-1199, by one of the following methods: In the Federal Register of February 6, 2008 (73 FR 6964) (FRL-8350-9), EPA issued a notice pursuant to section 408(d)(3) of FFDCA, 21 U.S.C. Although observed less consistently, increases in the activity of some enzymes indicated altered liver function as a response to uniconazole exposure. $}a!,ZlBk> s6nw!ZBAp"0kbExI] `%%$cY7-T5v>hT5}|S9^J P7dmy9h>xPAoB&b(1Ws6,#)p{iA,&Hn8nsw}T{1&mF"Jka%P. Although its not a Bad Actor on P.A.N.s list, its impacts on aquatic life is quite harsh. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For chronic dietary risk assessment, the water concentration of value 1.5 ppb was used to assess the contribution to drinking water. Dietary exposure from drinking water. The Docket Facility is open from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. The additional rib was the only skeletal variation noted, The fetal effect occurred only in the presence of maternal toxicity. // -->
PDF Uniconazole Retards Growth and Increases Flowering of Young - ASHS The reason for this change is explained in Unit IV.C.
Uniconazole P - Chemical Details | Chemical Search - US EPA Paclobutrazol is the most widely used growth retardant for greenhouse-grown floriculture crops in the U.S. <>
Register (ACFR) issues a regulation granting it official legal status. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.
PDF US005500404A United States Patent (19) 11) Patent Number: 5,500 A plant growth regulator used to reduce vegetative growth and increase flowering, Bedding plants including calibrachoa, celosia, petunia, salvia, scaevola, dahlia, marigold, verbena, viola; Woody landscape ornamentals; Tomatoes; Peppers; Cucumbers; Avocado, EC Regulation 1107/2009 (repealing 91/414), Approved for use () under EC 1107/2009 in the following EU Member States, Approved for use () under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries. It is commonly applied as a foliar spray and the trial rates of 5 to 90 ppm are listed for experimental use, but most commercial spray application rates are between 1 and 50 ppm. if (window != top) Reference to commercial products or trade names does not imply endorsement by MSU Extension or bias against those not mentioned.
Some of the following links exit EPA's site
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.. Furthermore, the conazoles produce a diverse range of biochemical events, including altered cholesterol levels, stress responses, and altered DNA methylation. developer tools pages. You may also access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Printing Office's pilot e-CFR site at http://www.gpoaccess.gov/ecfr. Growers often prefer the use of ancymidol on plugs because of the lack of phytotoxicity and it is a safer PGR to apply (because its limited residual allows the plugs to grow out of the growth control effects after being transplanted).
The assessment includes evaluations of risks for various subgroups, including those comprised of infants and children. EPA will submit a report containing this rule and other required information to the U.S. Senate, the U.S. House of Representatives, and the Comptroller General of the United States prior to publication of this final rule in the Federal Register. are not part of the published document itself. "Teams coming out of the spring thinking they need more help may make trade calls on Young,'' Breer writes, adding, "I know (Washington would) be open to listening.'' For more on Young and the . For non-threshold risks, the Agency assumes that any amount of exposure will lead to some degree of risk. Bad Actor and Aquatic Toxin, Fire Ants, spider mites, and reproductive toxins, Kids and cancer and Washington Apple Growers, A soil penetrating threat to your health, Membership to the bee-killing chemical class, The first-line treatment for Scabies, and military uniforms, Long lasting carcinogen worry in our water. Although conazoles act similarly in fungi by inhibiting ergosterol biosynthesis, there is not necessarily a relationship between their pesticidal activity and their mechanism of toxicity in mammals. Miconazole systemic is used in the treatment of: Brand names: Monistat, Monistat 7, Mitrazol, Monistat 3, Monistat 1 Combination PackDrug classes: topical antifungals, vaginal anti-infectives. Experimental use rates of 1 to 50 ppm are listed on the label, but most commercial spray application rates are between 0.5 and 25 ppm. MILWAUKEE-- ( BUSINESS WIRE )--Rockwell Automation, Inc. (NYSE: ROK), the world's largest company dedicated to industrial automation and digital . One way to reverse excessive stunting is to apply gibberellins A4 + A7 and benzyl adenine. 804(2). Quality standards dictate that most container-grown greenhouse crops be compact, have short internodes, have a height consistent with the container they are grown in and have strong stems. It is most commonly applied at rates between 1250 to 5000 parts-per-million (ppm). [Reserved], updated on 11:25 AM on Monday, June 12, 2023, updated on 8:45 AM on Monday, June 12, 2023. Uniconazole is not registered for any use patterns that would result in residential exposure. documents in the last year, 1055 It is active on a wide range of plants and acts by inhibiting the production of gibberellins. 06/12/2023, 245 III. In this study, an increased incidence of 14th rib in the fetuses was observed in the presence of minimal maternal toxicity (decreased body weight). Chemical formula: C18H14Cl4N2ODrugbank ID: DB01110ATC codes: A01AB09, D01AC02, A07AC01, J02AB01, G01AF04, S02AA13, G01AF20, D01AC52. Is a relatively recent introduction into the U.S. market, although it has been available in Europe since the 1990s. No Codex, Canadian, or Mexican MRLs have been established for uniconazole. EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the results of the studies to human risk. This chemical is commonly used on perennials because it is highly effective on a very broad range of plant species. Document Drafting Handbook It is approved for use in organic agriculture by numerous national and international certifications as well. documents in the last year, 84 EPA has determined that reliable data show the safety of infants and children would be adequately protected if the FQPA SF were reduced to 1X. Priti Pal, .
Uniconazole | C15H18ClN3O | CID 6436604 - PubChem For complete information about, and access to, our official publications Uniconazole can also be used as a drench, at rates 50% lower than recommended for paclobutrazol. Foliar chlormequat chloride applications often result in a phytotoxic response (chlorosis), but the symptoms are usually covered up with new leaf growth.