; Gellman, S.H. ; Coutinho, J.A.P. Consider the directing effects of the substituents on salicylamide and predict the possible structures of the iodination products. ; Carvalho, P.J. ; Borges, A.; Cordeiro, J.M.M. We use cookies on our website to ensure you get the best experience. 2011 Aug 1;21(15):4498-502. doi: 10.1016/j.bmcl.2011.05.125. Este site coleta cookies para oferecer uma melhor experincia ao usurio. Salicylamide has a hydroxyl group at the ortho position of benzalamide. ; Wood, P.A. ; Voronin, A.P. The guidance for solvent selection comes from computed solubility via COSMO-RS approach. Prat, D.; Hayler, J.; Wells, A. Salicylanilide is a chemical compound which is the amide of salicylic acid and aniline. ; Abranches, D.O. Soc. Evaluation of COSMO-RS for the prediction of LLE and VLE of water and ionic liquids binary systems. Property Value .
Salicylamide | CAS#:65-45-2 | Chemsrc - Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties. You seem to have javascript disabled. Comput. 14: Zarei AR, Afkhami A, Sarlak N. Simultaneous spectrophotometric determination of paracetamol and salicylamide in human serum and pharmaceutical formulations by a differential kinetic method. Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. Molar Mass: 137.136 g/mol: Molecular Formula: C 7 H 7 NO 2: NFPA 704: H-2,F-1,R-0 . ; Matxain, J.M. ; Silvestre, A.J.D. antipyretic analgesic for fever, headache, neuralgia, arthralgia, active rheumatism and other diseases. ; Gordeev, E.G. C10H16N2O2 Rahimpour, E.; Acree, W.E. ; Martnez, F. Preferential solvation of some sulfonamides in 1,4-dioxane + water co-solvent mixtures at 298.15 K according to the inverse Kirkwood-Buff integrals method. Przybyek, M.; Walczak, P.; Zikowska, D.; Grela, I.; Cysewski, P. Studies on the solidliquid equilibria and intermolecular interactions Urea binary mixtures with Sulfanilamide and Sulfacetamide. Differential molar heat capacities to test ideal solubility estimations. ; Ballantyne, D.J., Use of Dual-Column Fused-Silica Capillary Gas Chromatography in Combination with Detector Response Factors for Analytical Toxicology., J. U.S. Environmental Protection Agency. It is, however, a modern myth that Hippocrates used willow as a painkiller. ; Bhandarkar, S.V. ; Sosa, A.; Ortega, J.; Pinho, S.P. An example of a dilution calculation using the Tocris dilution calculator ; Schmidt, K.A.G. Average mass 137.136 Da. [18], Salicylic acid is a phenolic phytohormone, and is found in plants with roles in plant growth and development, photosynthesis, transpiration, and ion uptake and transport. 5-iodo salicylamide ; AKOS026739275 ; CS-0225164 ; View More. The answer of 19.713 mg appears in the Mass box. Brominated derivatives including dibromsalan, metabromsalan, and tribromsalan are used as disinfectants with antibacterial and antifungal activities. Huang, B.C. C1-C10. Enter 10 into the Concentration (start) box and select the correct unit (millimolar) 2004 Jan 1;64(1):429-34. 2003 Jun;20(6):926-30. Talanta. Evaluating the Role of Solubility in Oral Absorption of Poorly Water-Soluble Drugs Using Physiologically-Based Pharmacokinetic Modeling. Epub 2011 Dec 22. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Salicylic acid signaling in disease resistance. Jeschke, S.; Johansson, P. Predicting the Solubility of Sulfur: A COSMO-RS-Based Approach to Investigate Electrolytes for LiS Batteries. Its medicinal uses are similar to those of aspirin. ; Fernndez, N. Physicochemical characterization and simulation of the solidliquid equilibrium phase diagram of terpene-based eutectic solvent systems. Colomb. [54] Methyl salicylate is taken up by the stomata of the nearby plant, where it can induce an immune response after being converted back to salicylic acid. dimethyl sulfoxide (CAS: 67-68-5, 99.7) and N,N-dimethylformamide (DMF, CAS: 68-12-2, 99.8%) were obtained from Avantor (Gliwice, Poland). and M.P. A survey of solvent selection guides. ; Freire, M.G. [51] It plays a role in the resistance to pathogens (i.e. As such, it is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis. It is used in combination with both aspirin and caffeine in the over-the-counter pain remedies such as BC Powder and PainAid. Multiply the relative atomic mass by the molar mass constant. . What is the molar mass of Salicylamide? For this reason, the sediments collected after the shake-flask experiments for water and studied organic solvents were examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopyattenuated total reflectance (FTIR-ATR) techniques.
Chemical Database: Salicylamide, monosodium salt August 2, 2022 by Anonymous Salicylamide is an active ingredient in BC powder. ; Fuller, D.C., A simplified procedure for the isolation, characterization, and identification of weak acid and neutral drugs from whole blood, J. Anal.
Freire, M.G. Blake-Taylor, B.H. Press calculate ; Moniruzzaman, M.; Goto, M. Biocompatible ionic liquids and their applications in pharmaceutics. Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenine dinucleotide and noncompetitively with UDPG. ; Albericio, F. Green Solid-Phase Peptide Synthesis (GSPPS) 3. [5], If high concentrations of salicylic ointment are used topically, high levels of salicylic acid can enter the blood, requiring hemodialysis to avoid further complications. 1: Song XQ, Liu PP, Liu YA, Zhou JJ, Wang XL. Harten, P.F. systemic acquired resistance) by inducing the production of pathogenesis-related proteins and other defensive metabolites. 2009 Feb;44(2):869-76. doi: 10.1016/j.ejmech.2008.04.020. Generic Name. Chand, A.; Chowdhuri, S. Effects of dimethyl sulfoxide on the hydrogen bonding structure and dynamics of aqueous N-methylacetamide solution. J. No special 2016 May 10;45(19):8154-63. doi: 10.1039/c6dt00212a. Toxicol., 37, 1977, 295-305. ass: Standard non-polar; Column diameter: 0.53 mm; Column length: 10 m; Column type: Capillary; Heat rate: 5 K/min; Start T: 130 C; End T: 230 C; CAS no: 65452; Active phase: DB-1; Carrier gas: He; Phase thickness: 2.65 um; Data type: Normal alkane RI; Authors: Anderson, W.H. Allergy. PubMed PMID: 18968528. [23] Since oral aspirin (which produces much higher salicylic acid plasma concentrations than dermal salicylic acid applications) poses no significant adverse pregnancy outcomes in terms of frequency of stillbirth, birth defects or developmental delay, use of salicylic acid containing cosmetics is safe for pregnant women.[23]. ; Campana, F.; Marmottini, F.; Costantino, F.; Vaccaro, L. Extensive screening of green solvents for safe and sustainable UiO-66 synthesis. Freire, M.G. Interference by drugs contained in over-the-counter cold syrups on methamphetamine immunoassay test kits used in drug abuse assessment. 2-Hydroxybenzamide Resende De Azevedo, J.; Letourneau, J.J.; Espitalier, F.; R, M.I. ; Marrucho, I.M. Loschen, C.; Klamt, A. Cocrystal Ternary Phase Diagrams from Density Functional Theory and Solvation Thermodynamics. Subscribe to receive our lastest product updates and special offers! Cysewski, P.; Przybyek, M. Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index. Two dodecanuclear heterometallic [Zn6Ln6] clusters constructed by a multidentate salicylamide salen-like ligand: synthesis, structure, luminescence and magnetic properties. Res. Bryan, M.C. Name: Salicylamide 10: 3323. ; Arlt, W. COSMO-RS calculations of partition coefficients: Different tools for conformational search. . S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Prediction of infinite dilution activity coefficients of organic compounds in ionic liquids using COSMO-RS. inhibit ; Jimnez, D.M. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest. EAS occurs ortho or para to electron donating groups, such as amines, due to the stabilization of the intermediate . Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. ; Mller, S.; Gonzlez de Castilla, A.; Gurikov, P.; Matias, A.A.; Bronze, M.D.R. Derivatives of salicylamide include ethenzamide, labetalol, . Przybyek, M.; Zikowska, D.; Kobierski, M.; Mroczyska, K.; Cysewski, P. Utilization of oriented crystal growth for screening of aromatic carboxylic acids cocrystallization with urea. Pavli, B.; Mrkonji, .; Tesli, N.; Kljaki, A.C.; Poji, M.; Mandi, A.; Stupar, A.; Santos, F.; Duarte, A.R.C. 3: Manin AN, Voronin AP, Manin NG, Vener MV, Shishkina AV, Lermontov AS, Perlovich GL. DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro. ; Parker, S.F. Balchandani, S.; Singh, R. COSMO-RS Analysis of CO. Motlagh, S.R. Please note that many of the page functionalities won't work as expected without javascript enabled. ; Hadj-Kali, M.K. ; Raish, M. Solubility and dissolution thermodynamics of sinapic acid in (DMSO + water) binary solvent mixtures at different temperatures. Expert Answer 1st step All steps Final answer Step 1/3 To calculate the theoretical yield of iodinated salicylamide, we need to know the balanced chemical equation for the mono-iodination reaction and the amount of the starting material (reactant) used. Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. Moreover, in the case of the former amide, a significant co-solvation effect was observed for the aqueous binary solvent (x. Molar mass calculations are explained and there is a JavaScript calculator to aid calculations. Chlorinated derivatives including niclosamide, oxyclozanide, and rafoxanide are used as anthelmintics, especially as flukicides. 9: Kuziej J, Litinas E, Hoppensteadt DA, Liu D, Walenga JM, Fareed J, Jeske W. In vivo neutralization of unfractionated heparin and low-molecular-weight heparin by a novel salicylamide derivative. 15: Zhang L, Zhang JY. mol 1: 3D model (JSmol) Interactive image; Density: 1.33 g/cm 3: Solubility in . 19: MacDonald CJ, Ciolino HP, Yeh GC. ; Moffat, A.C., Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase, J. ; Uzor, P.F. . Fade, V. Link between drug absorption solubility and permeability measurements in Caco-2 cells. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. (1 u is equal to 1/12 the mass of one atom of carbon-12) Hernndez-Bravo, R.; Miranda, A.D.; Martnez-Mora, O.; Domnguez, Z.; Martnez-Magadn, J.M. Calculate the dilution required to prepare a stock solution. Toxicol., 11, 1987, 8-11. ass: Standard non-polar; Column type: Other; CAS no: 65452; Active phase: Methyl Silicone; Data type: Normal alkane RI; Authors: Ardrey, R.E. First, you can calculate the molar mass of FeCl2 by adding the molar masses of Fe (55.845 g/mol) and 2 atoms of Cl (2 times (35.446 g/mol). Pathogen inoculation did not produce the customarily high SA levels, SAR was not produced, and no PR genes were expressed in systemic leaves. ; Peel, H.W., Condierations in developing a data base for drugs on a DBI capillary column, J. Salicylamide is not only an important fine chemical intermediate, but also a widely accepted and widely used antipyretic analgesic sub, used for fever, headache, neuralgia, arthralgia and or active rheumatism, etc. Epub 2011 Sep 22. ; Scott, F.J. Cyrene. Crdenas, Z.J. 8: Murillo Pulgarn JA, Alan Molina A, Snchez-Ferrer Robles I. Its medicinal uses are similar to those of aspirin. The information is: webbook.nist.gov provides (external link), The information is: ofmpub.epa.gov provides (external link), The information is: pubchem.ncbi.nlm.nih.gov Provide (external link), Wuhan Xingzhongcheng Chemical limited company, Qianyan Chemical Technology (Wuhan) Co., Ltd, InChI=1/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10). Key Green Chemistry research areas from a pharmaceutical manufacturers perspective revisited. benzamide (CAS: 55-21-0, 99%), salicylamide (CAS: 65-45-2, 99%) and ethenzamide (CAS: 938-73-8, 97%) and 4-formylmorpholine (CAS: 4394-85-8, 99%) were purchased from Sigma-Aldrich (Pozna, Poland). Electrophilic aromatic substitution (EAS)This reaction mechanism takes place from bottom to top. most exciting work published in the various research areas of the journal. Prediction of solubilities and partition coefficients in polymers using COSMO-RS. Indeed, the subjects were more susceptible to virulent and even normally avirulent pathogens.
Salicylamide - ChemBK Wegner, K.; Barnes, D.; Manzor, K.; Jardine, A.; Moran, D. Evaluation of greener solvents for solid-phase peptide synthesis. 1993, Lawton et al. On the hydrogen bonding between N-methylformamide and acetone and tetrahydrofuran. .
Salicylamide | C7H7NO2 | CID 5147 - PubChem Neuroscience Surov, A.O. ; Peel, H.W., The use of retention indices and temperature-programmed gas chromatography in analytical toxicology, J. Chromatogr. and M.P. Where does electrophilic aromatic substitution occur? Calorimetric Determination of Cocrystal Thermodynamic Stability: Sulfamethazine-Salicylic Acid Case Study. The following supporting information can be downloaded at: Conceptualization, P.C. The present work reports the values of the gaseous standard (p = 0.1 MPa) molar enthalpies of formation of salicylaldehyde (2-hydroxybenzaldehyde) and salicylamide (2-hydroxybenzamide), at T = 298.15 K.For both molecules, those values were derived from measurements of the standard molar energy of combustion of the condensed compounds, using a static bomb calorimeter, together with . Wishart, D.S. Ciencias Exactas Fsicas y Nat. ; Thordal Le Quement, S.; Albericio, F.; Dettner, F.; et al. It is widely used in medicine, spices, dyes, many fields of rubber additives. Incompatible with strong bases, strong oxidizing agents. Venturi, D.M. All available data were provided in the manuscript and. ; Moine, G.; et al. Use the information This problem has been solved! Camp, J.E. The pH of saturated aqueous solution at 28 is about 5. Experimental Determination and Computational Prediction of Dehydroabietic Acid Solubility in ()--Pinene + ()--Caryophyllene + P-Cymene System. 10: Pulgarn JA, Molina AA. Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs. Furthermore, solute-solvent affinities computed using advanced quantum chemistry level were used as a rationale for observed solvents ranking. Jessop, P.G. ; Baboota, S.; Ali, J. It is used in combination with both aspirin and caffeine in the over-the-counter pain remedies such as BC Powder and PainAid. It has been found that the solubility of studied aromatic amides is very high and quite similar in all three aprotic solvents. ; Olasunkanmi, L.O. Plant Science 228:127134. InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10), https://en.wikipedia.org/w/index.php?title=Salicylamide&oldid=1125424265, Soluble in hot water, ether, alcohol, and chloroform. DrugBank Accession Number. Effectiveness of salicylamide as an analgesic and antirheumatic agent: Evaluation of the double blindfold technique for studying analgesic drugs. Inhibitor Forgot Password? 17: Medi-Sari M, Mornar A, Jasprica I. Lipophilicity study of salicylamide. Loschen, C.; Klamt, A. Solubility prediction, solvate and cocrystal screening as tools for rational crystal engineering. In veterinary medicine, this group of drugs is mainly used for treatment of inflammatory musculoskeletal disorders. Ferrazzano, L.; Corbisiero, D.; Martelli, G.; Tolomelli, A.; Viola, A.; Ricci, A.; Cabri, W. Green solvent mixtures for solid-phase peptide synthesis: A dimethylformamide-free highly efficient synthesis of pharmaceutical-grade peptides. PubMed PMID: 12817899. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). ; De Castro, C.S.P. ; Liffert, R.; Johansson Castro, H.; Krger, T.; Haselmann, K.F. ; Warren, J.E. Searching for green solvents. Molecular Weight. Batterman, R.C. ; Jensen, J.H. In relation to amine, its. 0 - 4 C for short term (days to weeks), or -20 C for long term (months). ; Parsons, S.; Pidcock, E.; Richardson, P.R. ; Manin, A.N. ; de Souza, M.C. ; Ventura, S.P.M. ; Ballantyne, D.J. 311331. ; Chang, B.L. Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. ; validation, P.C. Boling Point: 270C: Flash Point: 181C/14mm: Water Solubility: 0.1 g/100 mL at 20 C: . [42] Their extract caused digestive problems such as gastric irritation, bleeding, diarrhea, and even death when consumed in high doses. William Turner, in 1597, repeated this, saying that willow bark, 'being burnt to ashes, and steeped in vinegar, takes away corns and other like risings in the feet and toes. Delgado, D.R. Kumar, A.; Jad, Y.E. ; Mather, A.E. Stay updated with the latest chemical industry trends and innovations. Treatment with salicylamides leads to the bacterial growth inhibition which correlates with the level of inhibition of sulfate reduction [1]. Besuretoaddthesolvent(s)inorder. product Janardhan, S.; Ram Vivek, M.; Narahari Sastry, G. Modeling the permeability of drug-like molecules through the cell wall of: Mycobacterium tuberculosis: An analogue based approach. ; Forster-Carneiro, T.; Vzquez-Espinosa, M.; Gonzlez-de-Peredo, A.V. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid to the phenolic acceptor. Predicting pKa for proteins using COSMO-RS. Experimental solubility and density studies on aqueous solutions of quaternary ammonium halides, and thermodynamic modelling for melting enthalpy estimations. PubMed PMID: 15610614. Noteworthy, 4FM, which is considered green alternative for DMF was found to be a quite efficient solvent, especially for salicylamide and ethenzamide.
Designing Greener Solvents. New protocol for screening efficient and environmentally friendly solvents was proposed and experimentally verified. In, Such high solubility of salicylamide in all three studied aprotic solvents can be explained by the solute-solvent affinities documented in, The solubility of this aromatic amide is available in 18 neat solvents as enumerated in, To complete the analysis of ethenzamide solubility the COSMO-RS modeling was performed and the obtained results are collected in. Spie, A.C.; Eberhard, W.; Peters, M.; Eckstein, M.F. ; project administration, P.C. [23] Even in a worst-case use scenario in which one was using multiple salicylic acid containing topical products, the aggregate plasma concentration of salicylicic acid was well below what was permissible for acetylsalicylic acid (aspirin).
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