Kawanishi S., Oikawa S., Murata M. Evaluation for safety of antioxidant chemopreventive agents. Muralidar S., Ambi S.V., Sekaran S., Krishnan U.M. (L-OHP, oxaliplatin; 5-Fu, 5-fluorouracil; CPT-11, irinotecan; VCR, vincristine; GEM, gemcitabine; ADM, doxorubicin; DDP, cisplatin; and TAX, paclitaxel). (Patients will continue on curcumin at same dose for an additional 6 weeks while being treated with 3 cycles of 5-Fu). Zhu Y.J., Cheng J.L., Gao Z.G., Cui X., Li X.C., Chang B.C. Binder L.I., Frankfurter A., Rebhun L.I. The safety and toxicity of the compounds and special materials used to enhance bioavailability should be considered due to the excessive use of additives and colorants harmful to human health. Part B: Curcumin-mediated autophagy of cancer cells. Kim D.C., Ku S.K., Bae J.S. A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. Ringman J.M., Frautschy S.A., Cole G.M., Masterman D.L., Cummings J.L. Li J., Xiong K., Gong Y., Yu X. Valle A., Lecarpentier Y. Curcumin and Endometriosis. Kim M., Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Turmeric has a long history. Schiavoni G., Gabriele L., Mattei F. The tumor microenvironment: A pitch for multiple players. HHS Vulnerability Disclosure, Help ConsumerLab explains green tea's potential health benefits for everything from fighting cancer to helping your heart. Briefly, AD is a disease that seriously affects the physical and mental health of the elderly, with recent memory impairment and cognitive decline as the main symptoms [86]. Is curcumin high in oxalates? A study revealed that curcumin can downregulate the nuclear transcription factors AP-1 and NF-B and selectively inhibit the transcription of the HPV-16/E6 proto-oncogene [125]. Additionally, intervention with curcumin in advanced colon cancer showed that administration of up to 3600 mg daily for four months was well tolerated as a whole, with diarrhea and nausea in some cases, although these side effects were relieved by themselves [161]. Curcumin can affect the recruitment of IE gene promoters by RNA polymerase II mediated by viral transactivator protein vp16 through a pathway that is not dependent on the activity of transcriptional coactivator protein p300/CBP histone acetyltransferase, thereby inhibiting IE gene expression and inhibiting herpes simplex virus-1 (HSV-1) infection [127]. Zhu M., Zheng Z., Huang J., Ma X., Huang C., Wu R., Li X., Liang Z., Deng F., Wu J., et al. Curcumin functions mainly through the following mechanisms. Curcumin precursor liposomes can reduce the defect of poor stability and improve bioavailability in rats by more than 10 times [146]. miRNAs are single-stranded, non-coding, endogenous molecules containing 1825 nucleotides widely participating in the regulation of gene expression. Through modulation of the miR-21/tissue inhibitors of metalloproteinase 3 (TIMP3) and miR-21-5p/SOX6, curcumin inhibits the proliferation, migration and invasion of hepatocellular carcinoma cells [15]. It made a difference. Therefore, especially in patients with high-expression CYP2D6, the use of curcumin significantly reduces the pharmacokinetic parameters of tamoxifen and edoxifen, and patients may not be able to undergo optimal endocrine therapy. Deodhar S.D., Sethi R., Srimal R.C. Karthika C., Sureshkumar R., Sajini D.V., Ashraf G.M., Rahman M.H. For example, curcumin can significantly inhibit the long terminal repeat (LTR) of the human immunodeficiency virus (HIV) gene under the premise of not affecting cell activity and affect the virulence and replication ability of the virus [121]. Curcumin also has a certain inhibitory effect on common human pathogenic infectious viruses. The combination of 10M curcumin and 10 M 5-Fu may resensitize breast cancer cells to 5-Fu by downregulating thymidylate synthase-dependent nuclear factor-B (NF-B) [66]. Curcumin as well as . Therefore, in the use of curcumin, one should avoid combination medications to the greatest extent possible in order to prevent hypoglycemia and bleeding. Autophagy is closely related to apoptosis. Is ginger and turmeric good for kidneys? 2 months ago. Curcumin has been shown to help with the painful symptoms of both osteoarthritis and rheumatoid arthritis. Figure 2 partly demonstrates the effective mechanisms by which curcumin resensitizes drug-resistant cancer cells. Moreover, a miller developed delayed contact dermatitis after grinding turmeric powder, as did an elderly woman after use of turmeric powder dissolved in coconut oil for leg massage, both of whom presented with pruritus, erythema, papules and vesicles at the contact sites, with a positive curcumin patch test [173]. [93] proposed that curcumin could also reduce amyloid deposition by inhibiting the activity of glycogen synthase kinase 3 (GSK-3). Hyperoxaluria tied to eating foods with lots of oxalate. The significant lowering of the serum creatinine level is attributed to an enhanced GFR and the anti-lipid peroxidative property of the rutin and curcumin. EMT is among the important means by which epithelial tumor cells acquire invasive and metastatic abilities. For instance, curcumin can induce apoptosis of bladder cancer cells by downregulating miR-7641 [20] or miR-1246 [21]. Zhang T., He Q., Liu Y., Chen Z., Hu H. Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Baxmann A.C., De OG Mendona C., Heilberg I.P. Drug Induced Liver Injury Attributed to a Curcumin Supplement. in Relation to its Major Active Constituent Curcumin. Su P., Yang Y., Wang G., Chen X., Ju Y. Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells. Choe S.R., Kim Y.N., Park C.G., Cho K.H., Cho D.Y., Lee H.Y. Curcumin liposomes based on soy lecithin, nonionic surfactants and cholesterol can slow the rate of sustained curcumin release [137]. Kutluay S.B., Doroghazi J., Roemer M.E., Triezenberg S.J. Wang K., Tan S.-L., Lu Q., Xu R., Cao J., Wu S.-Q., Wang Y.-H., Zhao X.-K., Zhong Z.-H. Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer. In recent years, a number of studies have focused on the functions of microRNAs (miRNAs) in tumorigenesis. Chen J., Jiang L. Effect of curcumin combined with glibenclamide on glucose metabolism in type 2 diabetic rats and its mechanism. During British rule in India in the 15th century, curry powder mixed with turmeric and several other herbs was first used for medical purposes in humans [1]. Piperine can increase the absorption of curcumin, inhibit its glucuronidation and improve its bioavailability by more than 20 times [1]. Clin. [117]. Ospina-Romero M., Glymour M.M., Hayes-Larson E., Mayeda E.M., Graff R.E., Brenowitz W.D., Ackley S.F., Witte J., Kobayashi L.C. Giordano A., Tommonaro G. Curcumin and Cancer. Soetikno V., Sari F.R., Lakshmanan A.P., Arumugam S., Harima M., Suzuki K., Kawachi H., Watanabe K. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Weng Q., Cai X., Zhang F., Wang S. Fabrication of self-assembled Radix Pseudostellariae protein nanoparticles and the entrapment of curcumin. [168] also reported a case of autoimmune hepatitis induced by drugs containing curcumin supplements. Zhang X., Zhang H., Si L., Li Y. Curcumin mediates presenilin-1 activity to reduce -amyloid production in a model of Alzheimers Disease. Curcumin also has curative effects on chronic complications caused by diabetes. Is sprinkling turmeric on my food equivalent to taking a turmeric supplement? It has been found that curcumin exhibits excellent therapeutic potential for antiherpes virus treatment. Lanni C., Masi M., Racchi M., Govoni S. Cancer and Alzheimer disease inverse relationship: An age-associated diverging derailment of shared pathways. Fan et al. After the cytotoxic drug cyclophosphamide was intraperitoneally injected into rats pretreated with curcumin seven days prior, the proper chromosome arrangement and mitotic index were significantly decreased [171]. 1,25 (OH)2D is the most potent metabolite of vitamin D, and mediates most of its hormonal actions. [65] used a similar high-density 3D model to culture colon cancer cells HCT-116, MMR-deficient HCT-116 and their corresponding drug-resistant cells (HCT-116R, HCT-116 + ch3R) and found that curcumin combined with 5-Fu significantly enhanced colony division, induced cell apoptosis and inhibited cell proliferation. The keto or enol ring of curcumin interacts with the aromatic ring of -amyloid protein, damaging the -sheet, thereby inhibiting the generation and aggregation of senile plaques and promoting plaque decomposition [89,90]. An electrocardiogram showed complete atrioventricular blockage, and there were countless asymptomatic second-degree and Mohs type I atrioventricular blockages in one night. Chen C.P., Xu Q., Zhao H.F. Huang W.P., Wang H.Q., Guo T.T., Hu C.X. To assess the safety, tolerability, efficacy(measured by response rate with RECIST and overall survival in months). Long-term administration of antiherpes drugs leads to various adverse effects and drug resistance. A report on curcumin contents of turmeric dietary supplements in American city retail markets showed that 71% of the products contain solvent residues that meet the standard but are unnecessary components in the curcumin products. Rane J.S., Bhaumik P., Panda D. Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro. Bethesda, MD 20894, Web Policies Keihanian F., Saeidinia A., Bagheri R.K., Johnston T.P., Sahebkar A. Curcumin, hemostasis, thrombosis, and coagulation. Four ways to lower oxalate in the urine, in order of importance. Peng M.Y., Qiu F., Huang D., Qin X., Zhang D. Study on the reversal effect and mechanism of curcumin on nejicitabine of pancreatic cancer SW1990 cells. Lung tumor promotion by curcumin. Similarly, a clinical trial of curcumin intervention in high-risk groups of malignant tumors showed that three months of curcumin treatment (doses from 500 to 8000 mg/d) resulted in aggravation of histological precancerous lesions in individual patients after bladder cancer surgery, cervical intraepithelial neoplasia, intestinal metaplasia and Bowens disease [176]. Therefore, curcumin might have similar properties as an iron chelator, inducing iron failure [165]. Spice of Life: about Spices and Oxalate content Eventually, you'll get around to wondering: which spices are high in oxalate? [103] fed ApoE / mice a high-fat diet alone or in combination with curcumin and found that cholesterol accumulation in the aorta, cholesterol absorption in the small intestine and the degree of atherosclerosis decreased by 56%, 51% and 45%, respectively. RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Shakeri A., Cicero A.F.G., Panahi Y., Mohajeri M., Sahebkar A. Curcumin: A naturally occurring autophagy modulator. There were no significant changes in hematological and biochemical parameters. Pharmacokinetics and Intestinal Absorption of Curcumin Chitosan Hydrochloride Coated Liposome in Rats. udomov M., Hassan S. Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways. Do turmeric and curcumin supplements contain significant amounts of oxalates? Cao H.W., Yu H.J., Feng Y.G., Chen L., Liang F. Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis. 01 May 2008 Article history PDF Split View Cite Permissions Share ABSTRACT Background: High oxalate intake resulting from consuming supplemental doses of cinnamon and turmeric may increase risk of hyperoxaluria, a significant risk factor for urolithiasis. A single-layer tumor microenvironment coculture model of colon cancer HCT-116 cells and MRC-5 fibroblasts was proposed, and it was found that TGF-3, metastatic active adhesion molecules, proliferation-related proteins and EMT-related factors in HCT-116 cells were significantly upregulated. Deng S., Shanmugam M.K., Kumar A.P., Yap C.T., Sethi G., Bishayee A. Qian W.L., Gao X.B., Yu Z.W., Nan L.H. Curcumin may also decompose the formed TAU oligomers through regulation of the Nrf2/ARE pathway to reduce the oxidative stress damage of cells [97]. In addition to reviewing the outstanding potential of curcumin in a variety of diseases, we also focuses on the problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the difference in the purity of curcumin in the edible and medicinal fields, which may affect its maximum effect. What is the difference between turmeric spices used in the kitchen and turmeric supplements? It is possible that curcumin was sensitized by reacting with dust in the air during the grinding process, resulting in contact dermatitis. The effects of curcumin on blood sugar and platelet aggregation have been documented. After high-dose curcumin intervention, CD31 expression in malignant pleural mesothelioma tumors decreased significantly, suggesting that curcumin inhibited angiogenesis in tumors [57] (Figure 2). Lu Y., Zhang X.J., Zhang R.Z. It is noteworthy that the purity of curcumin is not necessarily proportional to the effect. Koo B.-B., Calderazzo S., Bowley B.G., Kolli A., Moss M.B., Rosene D.L., Moore T.L. The autophagy induced by curcumin in malignant tumor cells may mainly rely on the following three pathways: Inhibition of the PI3K/Akt/mTOR signaling pathway: Curcumin may induce autophagy in colon cancer cells HCT116 and SW620 by downregulating the activity of the Yes-associated protein (YAP) through inhibition of the IGF1/PI3K/Akt/mTOR pathway [33].
Oxalate-curcumin-based probe for micro- and macroimaging of - PNAS Curcumin also inhibits the proliferation of colon cancer cells through a miR-199b-5p-mediated mechanism to downregulate p21-activated kinase 4 (PAK4), phospho-mitogen-activated protein kinase (p-MEK), MEK, phospho-extracellularly regulated protein kinases (p-ERK) and ERK [18]. Research progress of curcumin pharmacokinetics and its anti-breast cancer effect. Calcium binds to oxalate and reduces oxalate absorption in the gut. Liu W.H., Yuan J.B., Yang L. Study on the mechanism of curcumin reversing the drug resistance of hesperidin in gastric cancer cells. Curcumin inhibits the proliferation, invasion and metastasis of these drug-resistant cell lines and promotes their apoptosis through a wide range of targets. Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., Ko J.Y., Lin J.T., Lin B.R., Ming-Shiang W., et al. Wei P., Li R.S., Wang H., Ren Y., Sun H.Y., Yang J.D., Wang P.W. [119] treated cells with curcumin in advance and then infected cells with TGEV and found that curcumin inhibited the proliferation of TGEV and the expression of viral-related proteins in a dose-, temperature- and time-dependent manner. ; 21B0359 for L.H. Moderate autophagy can protect cells, whereas excessive digestion and degradation of organelles cause the death of autophagic cells, i.e., autophagy-induced apoptosis [31]. Iron chelation in the biological activity of curcumin. Among them, curcumin separated from the dried rhizomes of turmeric is the main active component of turmeric, with a molecular formula of C21H20O6 (Figure 1). Zhejiang J. Integr. In vitro study of curcumin against AD by inhibiting the activity of GSK-3. Prasad S., Tyagi A.K., Aggarwal B.B. Takahashi M., Uechi S., Takara K., Asikin Y., Wada K. Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin. Curcumin may also inhibit HSV-2 replication by downregulating NF-B. Individual case reports of adverse effects manifested in the heart, liver, kidney, blood, reproduction and immune system cannot be ignored, and the fact that curcumin may have a cancer-promoting effect on populations with high risk factors for cancer or precancerous lesions requires careful attention. Figure 3 demonstrates the effective mechanisms by which curcumin resensitizes radio-resistant cancer cells. In vitro experiments have also proven that curcumin encapsulated with cyclodextrin may produce higher blood concentrations of curcumin [148]. Recently, Paxlovid and bebtelovimab were approved for marketing, but clinical evidence is limited, and there are skeletal adverse effects, with bebtelovimab is temporarily listed as an alternative therapy in the NIH guidelines. Find out which supplements, foods and beverages may increase or decrease the risk of kidney stones, including information about potassium, calcium, choline, turmeric and curcumin, vitamin C, as well as foods and beverages such as green tea, lemon juice, orange juice, cranberry juice, chocolate and almonds. Sun et al. Transient complete atrioventricular block associated with curcumin intake. Ye Xl Wang C.Y., Ting L., Xiong X.F., Wu M.J. Information about lemon juice, lemonade, orange juice, cranberry juice and other juices for increasing urinary citrate and reducing the risk of kidney stones. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. An in vivo experiment showed that there were no adverse effects when dogs or monkeys were given 3500 mg/kg curcumin orally [159]. Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimers disease brains: Implications for in-vivo diagnostics. This shows that curcumin still has a long way to go to practical clinical application. Kim M.J., Park K.-S., Kim K.-T., Gil E.Y. The peak values of aspartate transaminase (AST) and alanine aminotransferase (ALT) in laboratory tests were 20 times higher than the normal upper limit, but the AST and ALT levels decreased by 48% on the 7th day after curcumin supplementation was stopped, and transaminase returned to normal on the 42nd day [167]. Recent studies show that curcumin may affect the EMT process and MMPs secretion through miRNA- and lncRNA-mediated mechanisms. Although no literature reports the risk of hypoglycemia and bleeding when curcumin is used in combination, studies have shown that curcumin may delay the metabolism of glibenclamide by inhibiting the activity of CYP3A, which has a synergistic effect, along with glibenclamide, lowering blood sugar in type II diabetic rats [177]. People with gallbladder disease or calcium oxalate kidney stones and those trying to conceive should use turmeric/curcumin supplements with caution. For instance, in prostate cancer cells, curcumin inhibits cell proliferation through miR-145-mediated downregulation of cyclin D1 and cyclin-dependent kinases 4 (CDk4) or miR-30a-5p-mediated suppression of PCNA clamp-associated factor (PCALF) [12]. The potential targets of COVID-19 treatment are mainly spike (S) protein blocking, angiotensin-converting enzyme 2 (ACE2) inhibitor, etc. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. However, in the context of subclinical iron deficiency (iron intake < 1000 mg/kg), curcumin intake induced a concentration-dependent decrease in these blood parameters [166]. Liu X.P., Wang J.J., Wang M.Y. Curcumin may also play an indirect role in the control of blood lipids through anti-inflammatory and antioxidant pathways. We summarize the possible side effects of high-dose curcumin in the following sections (Table 1), although the majority of these events were isolated cases. www.consumerlab.com/answers/do-turmeric-and-curcumin-supplements-contain-significant-amounts-of-oxalates/turmeric-curcumin-kidney-stones/. Curcumin has become one of the worlds best-selling dietary supplements, with an increasing number of consumers favoring the ingredients extracted from natural plants. [32] used curcumin to treat oral squamous cell carcinoma (OSCC) cells. Chin. (9,10,23) Figure 2 partly summarizes the mechanisms by which curcumin induces autophagy in cancer cells. Is Turmeric Curcumin High Oxalate. This work was supported in part by the National Natural Science Foundation of China (81772842 for D.C., 81874408 for Y.H., 82104941 for F.Z. National Library of Medicine Acevedo-Guevara L., Nieto-Suaza L., Sanchez L.T., Pinzon M.I., Villa C.C. Chin. Kim J.Y., Cho T.J., Woo B.H., Choi K.U., Lee C.H., Ryu M.H., Park H.R. The polymorphism associated with the reduced expression of PIN1 has been associated with a reduced risk of cancers [85]. To asscess if curcumin can make tumor cells more sensitive to radiation therapy. Targeting autophagy using natural compounds for cancer prevention and therapy. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimers disease (AD), hematological diseases and viral infectious diseases. Interestingly, studies have shown that the rate of memory decline in patients with malignant tumors before and after diagnosis is lower than that of healthy people. In these models, the inflammatory indicators hs-CRP, TNF- and IL-6 decreased, and SOD activity increased. Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro. The secretion and aggregation of platelets is a complex cascade activated by epinephrine, adenosine diphosphate, platelet-activating factor, collagen and arachidonic acid [114]. Xu et al. Interestingly, researchers found high doses of BIOMOR Curcumin caused a healthy decrease in serum cholesterol. Med. Before Guo L.D., Jiao Z.X., Song Y., Teng W.-H., Liu Z., Liu J.-L. Study on the effect and mechanism of curcumin inducing apoptosis of colon cancer LoVo cells. Hi Denise! In vitro experiments also show that 300 g/mL curcumin can thoroughly inhibit the mobility of healthy human sperm [180]. Although there are not many reports on liver injury caused by curcumin, the existing reports emphasize the importance of curcumin supplementation as a triggering factor of drug-induced liver injury. Extensive evaluation is warranted. Hussaarts K.G., Hurkmans D.P., Hoop E.O.-D., van Harten L.J., Berghuis S., van Alphen R.J., Spierings L.E., van Rossum-Schornagel Q.C., Vastbinder M.B., van Schaik R.H., et al.
Oxalate and Kidney Stones | The Urology Group of Virginia Study on the mechanism of curcumin on the proliferation and apoptosis of colorectal cancer cells. However, one should limit the use of turmeric spice, especially if one is at a risk of developing kidney stones or other disorders related to high-oxalate content. Part C: Inhibition of angiogenesis by curcumin. Curcumin-induced contact urticaria may be mediated by immune- and non-immune-mediated mechanisms. Commercial turmeric or curcumin powders also usually contain additives. Cai et al. Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma. Zhang X., Li Y.
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